Other forms: wholesaling; wholesales; wholesaled
Use the adjective wholesale to describe something that's done on a big, broad scale, like wholesale changes made by a new government that affect an entire country.
It's pretty common to see the phrase "wholesale destruction," especially when historians are talking about the overwhelming effects of war or ecological disasters. When wholesale is a verb, it has a very different meaning — to sell things in bulk, usually to someone who is going to sell it again at a higher retail price. The earliest meaning of the word was "in large quantities," combining whole and sale into the phrase "by whole sale."