Something that's unmanned doesn't have a driver, pilot, captain, or anyone else controlling or steering it. An unmanned space mission is launched without human passengers or crew.
When a vehicle is unmanned, it's controlled from far away or by a robotic or autopilot system. Aerial vehicles like drones, surveillance planes, and spacecraft usually have cameras so that people on the ground can see what is happening nearby or beneath them. Other things are sometimes unmanned as well: "The reference desk was unmanned, so I couldn't ask my question."