Uncleanliness is a state of being grubby, filthy, grimy, or otherwise dirty. If you don't tidy up your room, your parents will give you a hard time about its uncleanliness.
If conditions are generally less than clean, that's uncleanliness. You can use this noun to talk about your friend's filthy car or the family dog after she's been wading in mud: "Sadie's uncleanliness means we're going to have to hose her off before we take her to the vet." Clean is at the heart of uncleanliness, from the Old English root clæne, "free from dirt or filth."