Use the adjective piebald to describe something that has different colored patches — especially black and white patches. If you own a piebald horse, you could name him Spot.
The adjective piebald is a combination of pie and bald. Pie was the original name for magpie, a common European bird known for its black and white coloring. Bald did not mean "hairless," but referred to a white patch, especially on the head (think bald eagle). So something piebald has a combination of black and white coloring. It mostly refers to horses, although the word can be used to describe other multicolored things.