If you suffer from neophobia, you're terrified of new things. Your neophobia might keep you from moving out of your dark, cramped apartment into a new house.
People with neophobia have deep anxiety and fear associated with any experience or thing that's new. If your grandmother seems scared to learn how to use a computer, it may be because of neophobia. The word is often used by biologists who study animals, too: the behavior of certain birds tends to be affected by neophobia. The word itself combines neo, or "new" in Greek, and phobos, or "fear."