If you're insusceptible to something, you're unlikely to be harmed or affected by it. The comic book hero Superman is famously insusceptible to everything except for Kryptonite; it's the only substance to which he's vulnerable.
If you've had the chicken pox vaccine, you'll be insusceptible to the chicken pox virus, and if you aren't interested in music, you're probablykrypto insusceptible to a particularly poignant, bittersweet melody that makes your friend cry. Kids who are insusceptible to TV commercials don't pay any attention to them (and don't beg their parents for the latest toys).