Arsenic is a chemical element that's quite poisonous to humans and other animals. Arsenic was once commonly used in rat poison and insecticides.
While arsenic is a naturally occurring element, it's often thought of as a poison used in mystery novels to murder people. Several kinds of agricultural bug killers once contained arsenic, but historically people have been more likely to suffer arsenic poisoning from natural leaching into water sources, like wells, or as a side effect of mining. Arsenic has a Greek root, arsenikon, from the Middle Persian zarnik, "gold colored."